When dealing with VMware be sure to adsujt the MTU on both the vSwitch and VMkernel interface. Changing only the vSwitch is similar to changing the physical switch MTU but not the hosts, it won't hurt anything but the ESXi hosts won't send packets larger than 1500.I'm a proponent of enabling jumbo frames, but I've also seen a lot of environments with issues due to inconsistent configuration. For example, jumbo frames enable on only some of the hosts. In my experience this results in occasional hangs in vMotion or NFS datastores going offline when accessed. Just something to watch out for.

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